Shōyō Hinata began playing volleyball after seeing the "small giants" who played the sport when he was in elementary school. He suffers a crushing defeat in his first and last tournament in middle school at the hands of his rival Tobio Kageyama. So, Hinata joins Kurasuno High School's volleyball team, vowing revenge against Kageyama. However, Kageyama is also on Kurasuno's team. The former rivals form a legendary combo with Hinata's mobility and Kageyama's precision ball-handling. Together, they take on the local tournaments and vow to meet Kurasuno's fated rival school in the nationals.

One fateful day, all of humanity was petrified by a blinding flash of light. After several millennia, high schooler Taiju awakens and finds himself lost in a world of statues. However, he's not alone! His science-loving friend Senku's been up and running for a few months and he's got a grand plan in mind, to kickstart civilization with the power of science!